Colon Rectal Surgeons Inc.

Completed Research Studies

Completed Research Studies

Dr. Alan Thorson

  • The Neuromuscular Stimulation System for Dynamic Anal Myoplasty.  November 1994-April 2000.  Medtronic, Inc.  Investigator.
  • Role of Peri-Strips as a Buttress in Intestinal Anasotmosis.  March 1996-December 1997.  Bio-Vascular, Inc. Principal Investigator.
  • The Importance of EGF Receptors in the Growth of Anal Squamous Cell Carcinoma. August 1997-June 1999.  Creighton University Health Futures Foundation.  Co-Investigator.
  • A Phase III Prospective Randomized Trial Comparing Laparoscopic Assisted Colectomy Versus Open Colectomy for Colon Cancer.  May 1998-October 2001.  National Cancer Institute Grant CA25224 to the North Central Cancer Treatment Group.  Institutional Principal Investigator.
  • Closure of Loop Ileostomy:  Decreasing the Length of the Operation with the Use of a Sodium Hyaluronate Based Bioresorbable Solution.  June 1998-February 2001.  Genzyme Corporation.  Investigator.
  • A Trial to Evaluate the Long-Term Tolerability, Safety, Subject Satisfaction, Pharmacokinetics and Use Patterns of Oral R108512 Tablets In Subjects With Chronic Constipation.  July 1998-April 2001.  Janssen Research Foundation. Investigator.
  • Arachidonic Acid Metabolism in Human Colon Cancer.  February 1999-April 2001. Section of Colon and Rectal Surgery, Creighton University.  Co-investigator.
  • Arachidonic Acid Metabolism in Inflammatory Bowel Disease.  February 1999-April 2001.  Section of Colon and Rectal Surgery, Creighton University.  Co-investigator.
  • Acticon® Neo-Sphincter Clinical Assessment.  October 1999-April 2003.  American Medical Systems.  Investigator.
  • A Phase II Study of Local Excision Alone or Local Excision Plus Adjuvant Chemoradiation Therapy for Small Distal Rectal Cancers.  December, 2001- January, 2003.  Cancer and Lymphoma Group B.  Investigator.
  • The Basis of Improved Prognosis in Human Colorectal Cancer Demonstrating High Microsatellite Instability.  March 2000-February 2001.  Section of Colon and Rectal Surgery, Creighton University.  Co-Investigator.
  • A Randomized Prospective, Multi-Centered Parallel Group Study Comparing the Traditional Surgical Treatment of Hemorrhoidal Disease to Stapled Hemorrhoidectomy Using the Circular Stapler.  May 2001-December 2003.  Ethicon Endo-Surgery, Inc.  Investigator.
  • A Prospective Study of the Prognostic Significance of Micro Satellite Instability in Patients with early Age-of-Onset Colorectal Cancer.  January 2004-December 2004. American College of Surgeons Oncology Group.  Investigator.
  • Timing of Rectal Cancer Response to Chemoradiation.  February 2004-current. National Institutes of Health #03451.  Institutional Principal Investigator.
  • Peri-Strips® with PSD Veritas® Collagen Matrix Staple Line Protection for Colorectal Surgical Procedures Post Marking.  August 2005-current.  Synovis Surgical Innovations.  Investigator.
  • An Open Multicenter Study to Evaluate the Efficacy and Safety of the NASHA/Dx For the Treatment of Fecal Incontinence. March 2006-current.  Q-Med Corporation. Investigator.

Dr. Charles Ternent

  • A Phase III prospective, randomized trial comparing laparoscopic-assisted colectomy versus open colectomy for colon cancer. 1995-2001.
  • Study of neuromuscular stimulation system for dynamic anal myoplasty.  1996-2000.
  • PYY gut hormone levels and GI motility following restorative proctocolectomy for refractory chronic ulcerative colitis. Thomas Adrian, PhD., Creighton University School of Medicine, Omaha, Nebraska, 1996-2000.
  • Lipoxygenase and cyclooxygenase induced inhibition of colorectal cancer cell growth. Creighton University, Omaha, Nebraska, Thomas Adrian PhD., 1996-2000.
  • Evaluation of the efficacy, the safety and the tolerability of XXX (enterokinetic) given subcutaneously in patients undergoing elective partial colectomies.  1997-1998.
  • A double-blind, placebo-controlled trial to evaluate the efficacy and safety of XXX tablets in subjects with chronic constipation.  1998-1999.
  • Arachidonic Acid Metabolism in Human Colon Cancer and in Inflammatory Bowel Disease.  1998-2001.
  • Closure of Loop Ileostomy: Decreasing the Length of the Operation with Use of a Sodium Hyaluronate-based Bioresorbable Membrane.  1998-2001.
  • A Trial to Evaluate the Long-Term Tolerability, Safety, Subject Satisfaction, Pharmacokinetics, and Use Patterns of Oral XXX Tablets in Subjects with Chronic Constipation.  1998-2001.
  • A two-period, double-blind, placebo-controlled trial to evaluate the effects of re-treatment of XXX on efficacy and safety in subjects with chronic constipation.  1999-2000.
  • A Randomized, Prospective, Multicentered, Parallel Group Study Comparing the Ferguson Closed Wound Surgical Treatment of Hemorrhoid Disease to Stapled Hemorrhoidectomy using the XXXXXX Circular Stapler.  2001-2004.
  • A Phase II Study of Local Excision Alone or Local Excision plus Adjuvant Chemoradiation Therapy for Small, Distal Rectal Cancer.
  • A Prospective Study of the Prognostic Significance of Microsatellite Instability in Patients with Early Age Onset of Colorectal Cancer.   2003-2005.
  • A Phase III Prospective Randomized Trial Comparing Laparoscopic-Assisted Resection versus Open Resection for Rectal Cancer.  2008-2010.
  • Timing of Rectal Cancer Response to Chemoradiation. 2003-present.
  • Clinical outcomes in a prospective institutional database of colorectal cancer patients and associated perioperative morbidity-mortality, survival and return of bowel function issues. 2004-present.
  • A Prospective, Multi-center, Randomized, Controlled, Third-Party Blinded Study of XXX to Prevent Parastomal Hernia Formation in Patients Undergoing Surgery for Permanent Abdominal Wall Ostomies. 2008-2012.
  • Impact of Routine Ostomy Intubation in Patients Who Undergo Permanent or Temporary Ostomy Creation.   2009-2014
  • Characterization of Outcome for Rare Colon and Rectal Tumors.  2010-2012.
  • A Phase 2 Prospective Evaluation of Immunotherapy for Perianal HPV Condylomata. 2012-2014.
  • Prospective Evaluation of Satisfaction and Quality of Life in Outpatient Anorectal Surgery. 2012-2015.
  • A Phase 3b, Randomized, Double-Blind, Placebo-Controlled, Parallel-Treatment Group, Multicenter Efficacy and Safety Study of XXXX in Subjects with Anal Fissure. 2013.
  • A Phase 3 Study of Efficacy and Safety of Topical XXX to Prevent Incisional Wound Infection in Colorectal Surgery Patients. 2014-2015.

Dr. Jennifer Beaty

  • A Prospective, Multi-center, Randomized, Controlled, Third-Party Blinded Study of XXX to Prevent Parastomal Hernia Formation in Patients Undergoing Surgery for Permanent Abdominal Wall Ostomies. 2008-2012.
  • Impact of Routine Ostomy Intubation in Patients Who Undergo Permanent or Temporary Ostomy Creation.   2009-2014
  • Characterization of Outcome for Rare Colon and Rectal Tumors.  2010-2012.
  • A Phase 2 Prospective Evaluation of Immunotherapy for Perianal HPV Condylomata. 2012-2014.
  • Prospective Evaluation of Satisfaction and Quality of Life in Outpatient Anorectal Surgery. 2012-2015.
  • A Phase 3b, Randomized, Double-Blind, Placebo-Controlled, Parallel-Treatment Group, Multicenter Efficacy and Safety Study of XXXX in Subjects with Anal Fissure. 2013.
  • A Phase 3 Study of Efficacy and Safety of Topical XXX to Prevent Incisional Wound Infection in Colorectal Surgery Patients. 2014-2015.

Colon and Rectal Surgery Completed Research Activities

Colon and Rectal Surgery- Anal Fissure

  • A Phase 3b, Randomized, Double-Blind, Placebo-Controlled, Parallel-Treatment Group, Multicenter Efficacy and Safety Study of XXXX in Subjects with Anal Fissure

Colon and Rectal Surgery- Anorectal Surgery

  • Patient Satisfaction After Outpatient Anorectal Surgery
  •  The Neuromuscular Stimulation System for Dynamic Anal Myoplasty
  •  Acticon™ Neosphincter

Colon and Rectal Surgery- Colon, Rectal, and Anal Cancer

  • Colon, Rectal, and Anal Cancer Database Study
  • Timing of Rectal Cancer Response to Chemoradiation
  • A Phase II Study of Local Excision Alone or Local Excision plus Adjuvant Chemoradiation Therapy for Small, Distal Rectal Cancer
  • A Phase II Multicenter, Randomized Trial Evaluating 3-Year Disease Free Survival in Patients with Locally Advanced Rectal Cancer Treated with Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-Operative Mangement
  • A Prospective Study of the Prognostic Significance of Microsatellite Instability in Patients with Early Age Onset of Colorectal Cancer
  • Characterization of Outcome for Rare Colon and Rectal Tumors
  • A Phase III Prospective Randomized Trial Comparing Laparoscopic- Assisted Resection versus Open Resection for Rectal Cancer
  • Arachidonic Acid Metabolism in Human Colon Cancer
  • The Basis of Improved Prognosis in Human Colorectal Cancer Demonstrating High Microsatellite Instability
  • Lipoxygenase and Cycloxygenase Induced Inhibition of Colorectal Cancer Cell Growth

 Colon and Rectal Surgery- Condyloma

  •  Phase II Study of the Treatment of Perianal Condyloma Acuminata with Intralesional Immunotherapy Using Skin Test Antigens

Colon and Rectal Surgery- Constipation

  • A Trial to Evaluate the Long-Term Tolerability, Safety, Subject Satisfaction, Pharmacokinetics, and Use Patterns of Oral XXX Tablets in Subjects with Chronic Constipation
  • A two-period, double-blind, placebo-controlled trial to evaluate the effects of re-treatment of XXX on efficacy and safety in subjects with chronic constipation.
  • A double-blind, placebo-controlled trial to evaluate the efficacy and safety of XXX tablets in subjects with chronic constipation

Colon and Rectal Surgery- Inflammatory Bowel Disease

  • Arachidonic Acid Metabolism in Inflammatory Bowel Disease

Colon and Rectal Surgery- Hemorrhoids

  • A Randomized, Prospective, Multicentered, Parallel Group Study Comparing the Ferguson Closed Wound Surgical Treatment of Hemorrhoid Disease to Stapled Hemorrhoidectomy using the XXXXXX Circular Stapler

Colon and Rectal Surgery- Ostomy Closure

  • Closure of Loop Ileostomy: Decreasing the Length of the Operation with Use of a Sodium Hyaluronate-based Bioresorbable Membrane

Colon and Rectal Surgery- Ostomy Creation

  • Impact of Routine Ostomy Intubation in Patients Who Undergo Permanent or Temporary Ostomy Creation

Colon and Rectal Surgery- Parastomal Hernia

  • A Prospective, Multi-center, Randomized, Controlled, Third-Party Blinded Study of XXX to Prevent Parastomal Hernia Formation in Patients Undergoing Surgery for Permanent Abdominal Wall Ostomies

Colon and Rectal Surgery- Surgery

  • Evaluation of the efficacy, the safety and the tolerability of XXX (enterokinetic) given subcutaneously in patients undergoing elective partial colectomies

Colon and Rectal Surgery- Surgical Wound Infections

  • Phase 3 Study of Efficacy and Safety of Topical XXX to Prevent Incisional Infections among Colorectal Surgery Patients

Colon and Rectal Surgery- Ulcerative Colitis

  • PYY Gut Hormone Levels and GI Motility Following Restorative Proctocolectomy for Refractory Chronic Ulcerative Colitis